FITC标记的广谱细胞角蛋白PCK抗体
产品名称： FITC标记的广谱细胞角蛋白PCK抗体
英文名称： Anti-pan-cytokeratin/FITC
产品编号： HZ--5352R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-pan-cytokeratin/FITC Conjugated antibody
FITC标记的广谱细胞角蛋白PCK抗体
| 英文名称 | Anti-pan-cytokeratin/FITC |
| 中文名称 | FITC标记的广谱细胞角蛋白PCK抗体 |
| 别 名 | P-CK; pan-cytokeratin; pan-CK; pan CK; wide spectrum Cytokeratin; Cytokeratins; [CK4; CK75; CK3; CK2; CK6C; CK6A; keratin 6E]. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human pan-cytokeratin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. The cytokeratins are encoded by a family encompassing 30 genes. Among them, 20 are epithelial genes and the remaining 10 are specific for trichocytes. In the cytoplasm, the keratin filaments conform a complex network which extends from the surface of the nucleus to the cell membrane. Numerous accessory proteins are involved in the genesis and maintenance of such structure. This association between the plasma membrane and the nuclear surface provides important implications for the organization of the cytoplasm and cellular communication mechanisms. Apart from the relatively static functions provided in terms of supporting the nucleus and providing tensile strength to the cell, the cytokeratin networks undergo rapid phosphate exchanges mediated depolymerization, with important implications in the more dynamic cellular processes such as mitosis and post-mitotic period, cell movement and differentiation. Cytokeratins interact with desmosomes and hemidesmosomes, thus collaborating to cell-cell adhesion and basal cell-underlying connective tissue connection. Subcellular Location: Cytoplasmic. Tissue Specificity: epithelial cells Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
细胞角蛋白是在上皮组织的胞浆内细胞骨架中发现的含角蛋白的中间丝蛋白。细胞角蛋白是由包含30个基因的家族编码的。其中，20种是上皮基因，其余10种是毛细胞特异的。在细胞质中，角蛋白丝形成一个从细胞核表面延伸到细胞膜的复杂网络。许多辅助蛋白参与这种结构的发生和维持。质膜和核表面的这种联系对细胞质的组织和细胞通讯机制提供了重要的意义。除了在支持细胞核和向细胞提供拉伸强度方面提供的相对静态的功能外，细胞角蛋白网络还经历磷酸盐交换介导的快速解聚，在诸如有丝分裂等更动态的细胞过程中有重要意义。有丝分裂期、细胞运动和分化。细胞角蛋白与桥粒和半桥粒相互作用，从而与细胞-细胞粘附和基础细胞底层的结缔组织连接协作。