FITC标记的锌指蛋白81抗体
产品名称： FITC标记的锌指蛋白81抗体
英文名称： Anti-ZNF81/FITC
产品编号： HZ-12210R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ZNF81/FITC Conjugated antibody
FITC标记的锌指蛋白81抗体
| 英文名称 | Anti-ZNF81/FITC |
| 中文名称 | FITC标记的锌指蛋白81抗体 |
| 别 名 | HFZ20; Zinc finger protein 81; ZNF81; ZNF81_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 76kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Human ZNF81 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF81, also known as HFZ20 or MRX45, is a transcriptional regulator belonging to the Krüppel C2H2-type zinc-finger protein family. It localizes to the nucleus and contains 12 C2H2-type zinc fingers and 1 KRAB domain. Mutations in the gene encoding ZNF81 are implicated in nonsyndromic X-linked mental retardation (XLMR). Function: May be involved in transcriptional regulation. Subcellular Location: Nucleus. DISEASE: Defects in ZNF81 are the cause of mental retardation X-linked type 45 (MRX45) [MIM:300498]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Note=A chromosomal aberration involving ZNF81 is found in a severe mental retardation patient. Translocation t(X;9)(p11.23;q34.3). Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 12 C2H2-type zinc fingers. Contains 1 KRAB domain. Database links: UniProtKB/Swiss-Prot: P51508.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
锌指蛋白含有DNA结合结构域，具有多种功能，其中大多数包含某种形式的转录激活或抑制。大多数锌指蛋白包含Krüppel型DNA结合域和KRAB域，它们被认为与KAP1相互作用，从而募集组蛋白修饰蛋白。ZNF81，也称为HFZ20或MRX45，是属于Krüppel C2H2型锌指蛋白家族的转录调节剂。它定位于细胞核，含有12个C2H2型锌指和1个KrAb结构域。编码ZNF19基因的突变与非综合征型X连锁精神发育迟滞（XLMR）有关。