FITC标记的中性鞘磷脂相关因子抗体
产品名称： FITC标记的中性鞘磷脂相关因子抗体
英文名称： Anti-NSMAF/FITC
产品编号： HZ-13656R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NSMAF/FITC Conjugated antibody
FITC标记的中性鞘磷脂相关因子抗体
| 英文名称 | Anti-NSMAF/FITC |
| 中文名称 | FITC标记的中性鞘磷脂相关因子抗体 |
| 别 名 | Factor associated with N SMase activation; Factor associated with neutral sphingomyelinase; Factor associated with neutral sphingomyelinase activation; FAN; Neutral sphingomyelinase (N SMase) activation associated factor; Protein FAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 生长因子和激素 细胞膜受体 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 104kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NSMAF |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors (1,2). These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types (1,3). The majority of TNF functions are primarily mediated through TNF-R1 (1,4). FAN (for factor associated with neutral sphingomyelinase (N-SMase) activation) is an intermediate protein that interacts with TNF-R1 to initiate TNF signaling events. FAN binds to TNF-R1 at the cytoplasmic NSD (N-SMase activating domain), which results in the initiation of the N-SMase pathway (5). N-SMase has been shown to be involved in TNF-induced Raf-1 activation (6). FAN contains four carboxy-terminal WD-repeat domains which appear to be involved in protein-protein interaction. The FAN WD-repeats may mediate the interaction between FAN and TNF-R1 (5). Function: NSMAF is a novel adaptor protein which mediates the activation of sphingomyelinase by receptors such as tumor necrosis factor receptor type 1 and CD40 and subsequent apoptosis in cardiomyocytes. Inhibition of this factor may provide a novel intervention point for reducing ischemia/reperfusion injury. Tissue Specificity: Ubiquitous. Similarity: Contains 1 BEACH domain. Contains 1 GRAM domain. Contains 6 WD repeats. Database links: Entrez Gene: 8439 Human Entrez Gene: 18201 Mouse Entrez Gene: 353233 Rat Omim: 603043 Human SwissProt: Q92636 Human SwissProt: O35242 Mouse SwissProt: Q7TSY5 Rat Unigene: 372000 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
肿瘤坏死因子（TNF）是一种多效性细胞因子，其功能通过两个不同的细胞表面受体（1，2）介导。这些受体，指定TNF- R1和TNF- R2，在大多数细胞类型（1，3）上表达。大多数TNF功能主要通过TNF-R1（1，4）介导。FAN(用于与中性鞘磷脂酶(N-SMase)激活相关的因子)是一种与TNF-R1相互作用以启动TNF信号转导事件的中间蛋白。FAN在细胞质NSD(N-SMase激活结构域)与TNF-R1结合，导致N-SMase途径的启动(5)。N-SMAX已被证实参与TNF诱导的RAF-1激活（6）。Fe包含四个羧基末端WD重复结构域，其似乎参与了蛋白质-蛋白质相互作用。风扇WD重复可能介导风扇和TNF- R1（5）之间的相互作用。