官方网址：http://www.sinobiological.cn/IFN-beta-Protein-g-4468.html
Interferon beta / IFN-beta / IFNB Protein 
 
 
 
 
 
 
 
 IFN-beta / IFNB Protein Price Inquiry ( Available Sizes )
 
 
 
200μg:  询价;
 
≥1mg 大包装:  询价
 
 
 
IFN-beta / IFNB蛋白产品信息
 
 
 
 
别名:
 
IFNB1,  IFB,  IFF,  IFNB,  MGC96956 
 
 
 
 表达方式:
 
A DNA sequence encoding the human IFNβ ( NP_002167.1 ) ( Met 1 - Asn 187 ) was expressed and purified
 
 
 
种属:
 
Human 
 
 
 
表达宿主: 
 
CHO stable cells
 
 
 
 
IFN-beta / IFNB蛋白质控指标
 
 
 
 
纯度:
 
> 92 % as determined by SDS-PAGE
 
SDS-PAGE:
 
 
IFNB protein
 
 
 
内毒素:
 
< 1.0 EU per μg of the protein as determined by the LAL method
 
 
 
稳定性:
 
Samples are stable for up to twelve months from date of receipt at -70℃
 
 
 
预测N端: 
 
Met 22
 
 
 
分子量:
 
The recombinant human IFNβ consists of 166 amino acids and has a predicted molecular mass of 20 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh IFNβis approximately 22 -24 kDa.
 
 
 
缓冲液:
 
Lyophilized from sterile 20mM  HEPES, 150mM NaCl, pH 7.2 
 
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
 
Please contact us for any concerns or special requirements.
 
 
 
 
 
IFN-beta / IFNB蛋白使用指南
 
 
 
储存方法:
 
 Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. 
 
 
 
 
Reconstitution: 
 
 A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
 
 
 
 
 IFN-beta / IFNB蛋白背景综述
 
 
Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily, and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, parasites and tumor cells. IFNs are produced by a wide variety of cells in response to the presence of dsRNA, a key indicator of viral infection via a pattern recognition receptor of the innate immune system Toll Like Receptor 3 (TLR 3), and in turn assists the immune response by inhibiting viral replication within host cells, activating natural killer cells and macrophages, increasing antigen presentation to lymphocytes, and inducing the resistance of host cells to viral infection. There are three major classes of IFNs according to the receptor type through which they signal, and the type I IFNs bind to a specific receptor complex known as the IFN-α receptor (IFNAR) consisting of IFNAR1 and IFNAR2 chains. The type I IFNs present in humans are IFN-α, IFN-β and IFN-ω and IFN-β is produced by fibroblast. In addition to the common antiviral activity, IFN-β also induces increased production of the p53 gene product which promotes apoptosis, and thus has therapeutic effect against certain cancers. Furthermore, IFN-β might play a beneficial role in the development of a chronic progressive CNS inflammation.
 
 
IFN-beta / IFNB蛋白相关产品和研究主题
 
 
相关研究领域:
 
蛋白:
 
抗体:
 
 
参考文献
 
 
 
Morikawa, K. et al., 1987, J. Immunol. 139: 761-766.
 
Sato, K. et al., 2001, Eur. J. Immunol. 31: 3188-3146.
 
Takaoka, A. et al., 2003, Nature. 424: 516-523.
 
Improta, T and Pine, R. et al., 1997, Cytokine. 9: 383-393.
 
Teige, I. et al., 2006, J. Immunol. 177: 3542-3553.