FITC标记的Rap1A抗体
产品名称： FITC标记的Rap1A抗体
英文名称： Anti-RAP1A/FITC
产品编号： HZ-1504R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-RAP1A/FITC Conjugated antibody
FITC标记的Rap1A抗体
| 英文名称 | Anti-RAP1A/FITC |
| 中文名称 | FITC标记的Rap1A抗体 |
| 别 名 | C21KG; RAP1; G 22K; G-22K; GTP binding protein smg p21A; GTP-binding protein smg p21A; KREV 1; KREV-1; KREV1; OTTHUMP00000013741; RAP 1A; RAP1; RAP1A; RAP1A member of RAS oncogene family; RAP1A_HUMAN; Ras related protein Krev 1; Ras related protein Rap 1A; RAS related protein RAP1A; Ras-related protein Krev-1; Ras-related protein Rap-1A; SMGP21; rap1a; RAS-related protein-1a precursor; Rap1A-retro2; RAP1A, member of RAS oncogene family. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 21kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RAP1A |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. Function: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. Subunit: Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (active GTP-bound form preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation of KRIT1. In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3. Interacts (via GTP-bound active form) with RAPGEF2 (via Ras-associating domain) Subcellular Location: Cell membrane; Lipid-anchor. Cytoplasm. Cytoplasm, perinuclear region. Cell junction. Early endosome. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions. Colocalized with RAPGEF2 in the perinuclear region. Similarity: Belongs to the small GTPase superfamily. Ras family. Database links: Entrez Gene: 5906 Human Entrez Gene: 109905 Mouse Entrez Gene: 295347 Rat Omim: 179520 Human SwissProt: P62834 Human SwissProt: P62835 Mouse SwissProt: P62836 Rat Unigene: 190334 Human Unigene: 458171 Mouse Unigene: 106321 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. RAP1A 是RAS癌基因家族成员，在调节细胞增生和粘附中有重要作用.经研究发现,Rap1和它的调节子SPA-1在很多恶性肿瘤的发生、发展中起到一定的作用。定位于胞浆、胞膜 |
该基因编码Ras家族的小GTP酶的成员。编码的蛋白质在构象状态和活性上发生变化，这取决于它是否与GTP或GDP相关。该蛋白被几种鸟嘌呤核苷酸交换因子（GEF）激活，并且被两组GTP酶激活蛋白（GAP）灭活。因此，编码蛋白的激活状态受GEF和间隙内细胞水平的平衡的影响。该编码蛋白调节影响细胞增殖和粘附的信号传导途径，并可能在肿瘤恶性肿瘤中发挥作用。该基因的假基因已被定义在染色体14和17上。选择性剪接导致多个转录变体。[ RefSeq，2014年5月提供]。