FITC标记的染色质修饰蛋白CHMP7抗体
产品名称： FITC标记的染色质修饰蛋白CHMP7抗体
英文名称： Anti-CHMP7/FITC
产品编号： HZ-13916R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CHMP7/FITC Conjugated antibody
FITC标记的染色质修饰蛋白CHMP7抗体
| 英文名称 | Anti-CHMP7/FITC |
| 中文名称 | FITC标记的染色质修饰蛋白CHMP7抗体 |
| 别 名 | Charged multivesicular body protein 7; CHMP family member 7; Chromatin modifying protein 7; CHMP7_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 51kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CHMP7 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The charged multivesicular body proteins or chromatin modifying proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), as well as required for the formation of these bodies. CHMP7 is an ESCRT-III-related protein that associates with CHMP4B. CHMP7 contains an SNF7 domain in the C-terminus and is most similar to CHMP6. CHMP7 also binds to the microtubule interacting and transport (MIT) domain of the deubiquitinating enzyme, UBPY. The overexpression of CHMP7 inhibits EGFR degradation. Function: CHMP7 plays a role in the endosomal sorting pathway and is a component of the ESCRT III complex. Subunit: Interacts with CHMP4B, but not with VPS25. Subcellular Location: Cytoplasm. Note: Diffused localization, with some punctate distribution, especially in the perinuclear area Similarity: Belongs to the SNF7 family. Database links: Entrez Gene: 91782 Human Omim: 611130 Human SwissProt: Q8WUX9 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
带电多泡体蛋白或染色质修饰蛋白，通常称为CHMP，属于液泡分选蛋白家族，具有染色质修饰蛋白的功能。CHMP1-6都是ESCRT的组成部分（转运所需的内体分类复合物）I、II或III复合物。这些复合物对于将内体物品分选成多泡体（MVB）以及形成这些体所必需的是至关重要的。CHMP7是与CHMP4B相关的ESCRT-III相关蛋白。CHMP7在C端包含SNF7结构域，与CMP6最相似。CHMP7还与去泛素化酶UBPY的微管相互作用和转运（MIT）结构域结合。CHMP7的过度表达抑制了EGFR的降解。